I'm proud owner of a SpacePilot even though most of my work happens ins 2D using Photoshop CS4.
For more usability I now tried to assign some custom keystroke for Adobe Lightroom but they won't work. I tried to assign single keystrokes as well as multiple strokes, but they won't fire. If I assign a predefined stroke like Space-Bar that works but my own keystrokes are not send to any application I tried.