Universal Cosmonaut is a tray icon application, not a driver - that means it'll run on 64 bit, but its only emulating mouse and keyboard. It allows you to set up different configurations for every application (samples for iTunes and Windows Media Player included), and automatically switches them based on the application currently in the foreground.
download (blog page)

No fancy 3D images on that settings dialog, but I'm not good enough at graphics on my own, and didn't want to violate 3DConnexions copyright by just ripping them out of the official driver.
