This also might help to be on record:
I use an older Space Mouse Compact model. My graphics card is an Nvidia Quadro M2000. I use it primarily for Autodesk Inventor CAD software. I've had drifting symptoms for many months now, but it seems to be sorted now.
The symptoms first showed up with my web browsers ghost scrolling. I had no idea at this stage that it was the space mouse causing this, as I didn't realise it talked with the windows GUI (lots of cursing at Microsoft!). It got worse, and not long after I noticed that my Inventor software would rotate models without my input.
I realised not long after that the browser & CAD drifting were the same symptom, so I would calibrate the Space Mouse, and the problem would go away for the day's session. However, it got progressively worse over the next few weeks, to the point where I would need to calibrate the SM every half hour or so. For the Win10 environment, using the SM setup menu, I set the windows control inputs to zero, but the drifting continued in Windows despite this. As a temporary fix, when I was browsing, I would start the SM calibration, but not click OK on the dialog box, thus suspending the calibration. This would stop any drifting in the Windows environment, but disable navigation in my Inventor environment.
Recently, I was having PC stability problems triggered by the latest Win10 updates (blue screen, roll-backs, delay updates etc). Sometimes my monitors would just blank out during this instability period (no signal). This prompted me to swap my monitor cables to different sockets on my graphics card outputs. As this worked occasionally, I thought I may have fixed my instability with Win10 updates problem. Nope. It got worse, until even the cable swapping had no effect. At this point I couldn't use my PC at all.
Seeing as it was the Graphics card as the biggest problem now, I opened up my PC and noted a spare PCIe slot, so swapped the Quadro into this spare slot.
So far, 10 days in no drifting on the Space Mouse. Plus, stable system on the rolled back Win10 configuration. Fingers crossed!